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Biology, Medicine and Health

The integration of discovery biology, clinical application and patient care within a single Faculty, particularly in a region with notable health inequality, provides us with a real opportunity to have a very significant and positive impact on people’s lives.

Scale of activity

Our size allows a breadth of research activity that can be matched by few universities. We have an annual budget of over £300 million and research income in the region of £150 million a year. We employ 3,200 members of staff and currently offer 34 undergraduate and 90 postgraduate taught programmes. The Faculty is home to around 11,200 students, including 1,300 from overseas, and is the biggest supplier of health-care graduates to the NHS in the north-west of England.

We have a diverse portfolio of the highest quality teaching and research activity, represented through our component Schools and research domains. Our scale, breadth and structure provide outstanding opportunities for biomedical research discoveries to be rapidly translated into effective new therapies with a strong emphasis on knowledge transfer and partnerships with industry.

Our academics have access to the large, stable population in the North West providing unique opportunities to study and address most causes of disease and deprivation. The opportunities are further enhanced by strong links to our partner Faculties (Humanities, and Science and Engineering) and the NHS.

Impact and collaboration

The Faculty’s mission is to produce innovative research that benefits society in Manchester, the UK and across the globe. To achieve this, we have established a number of strategic partnerships, principally with NHS partners in the Manchester Academic Health Science Centre (MAHSC). This in turn helps us take full advantage of the unique funding opportunities presented by the UK government’s DevoManc health-care agenda, which has allowed Greater Manchester to take control of its £6 billion annual budget for health and social care.

Research and funding links are in place with a number of commercial organisations, including Unilever, AstraZeneca, GlaxoSmithKline and Boots, helping us bring new drugs to the market. Other key partnerships include Cancer Research UK, Diabetes UK, the British Heart Foundation and the Wellcome Trust.

As a leading centre of excellence across the biological, medical and health sciences, with a strong focus on addressing key health challenges, both locally and globally, we have adopted and developed a truly collaborative, partnership approach to every aspect of our work that sets us apart.

By joining our Faculty you’ll help us to realise our ambitious aims and objectives, and work towards delivering our three core priorities:

  • Development and delivery of the highest quality education and training for health professionals and scientists,
  • Conducting outstanding, world leading research in the biomedical and health sciences,
  • Social responsibility: making a contribution to the greater good,

Areas of interest

We’re interested in receiving applications from the following areas, although strong applications from other disciplines within biology, medicine and health will be considered.

Advanced materials for medicine and health

Novel medical approaches to improve human health and well-being are essential for maintaining the UK’s internationally leading position in medical technology. A new generation of smart biomaterials is required.

Biomedical materials is a key theme within our Henry Royce Institute and we intend to accelerate the discovery, manufacture and translation of biomaterials through a platform of state-of-the-art equipment.

Our two identified grand challenges of advanced biomaterials research are restoring biological function with minimal invasiveness, such as by regenerative medicine, novel prosthetics and implants, and developing new therapies that reduce patient risk and improve efficacy at lower cost.

Ageing populations

The ageing of the population raises crucial economic, social and health-care challenges. Improvements to health, autonomy and well-being in later life might come from advances in biological and medical science; development of new technologies and materials; reorganisation of health and social care; organisational changes and changes in the ways we organise societies and improved physical and social environments.

Research into this wide array of issues is especially important in the context of a population that faces substantial inequalities across the life course, such as that in the Greater Manchester area, where high proportions need health and social care, and there are wide disparities in participation in economic, social and civic life.

Particular areas of strength in ageing research at University of Manchester include:

  • Social ageing – Research into longitudinal, life-course perspectives; ageing and inequalities; global ageing; environments of ageing including urban infrastructures; work, pensions and retirement; financial gerontology; job redesign and organisational change; and ageing and everyday life.
  • Ageing and health – Research into public health and falls; care services and care; technology and ageing; those with chronic disease such as arthritis, stroke, cardiovascular disease, diabetes, cancers and dementias; and those ageing with disabilities such as deafness and blindness, mobility problems, and problems with the activities of daily living.
  • Biological ageing – research into the biological mechanisms behind how we age, why we age, and why age-related chronic illnesses develop. This research brings potential for the development of treatments and interventions that improve well-being in later life.

Biomedical imaging and image computing

Imaging and image computing exploit technology to provide new insights in biomedical research and new tools for clinical practice. We want to integrate strengths in imaging technology, bioimaging, preclinical imaging, clinical imaging and image computing (reconstruction, visualisation and analytics) to generate impact, with particular emphasis on opportunities presented by access to very large data sets and links to other data sources, such as genomics.

Cancer

We provide a world-leading research environment in cancer sciences. A designated cancer research domain exists within the Faculty with established interactions and engagement with the Cancer Research UK (CRUK) Manchester Institute, the Manchester Cancer Research Centre (MCRC) and The Christie NHS Foundation Trust.

Priority areas include:

  • Prevention and early detection of cancer – Using a targeted, genomic-based approach to identify and study at-risk populations with the aim of earlier detection.
  • Living longer with cancer – DevoManc allows our researchers a unique opportunity to study the physical and psychological implications of longer-term cancer survival, for the individual (eg side effects of chemotherapy, early detection of recurrence), their relatives, and for the population and health service as a whole.
  • Cancer immunology – combining research in inflammatory disease and cancer biology to study the role of inflammation in the early development of many tumour types.

Cell matrix and biological timing

Our Cellular and Developmental Systems research domain focuses on understanding how basic cell and developmental biology processes, such as cell fate, cell division, cell-cell and cell-matrix interactions, and cell migration are achieved, and coordinated in space and time to make, maintain and repair complex multicellular organisms. This highly interdisciplinary research area, coupled with our state-of-the-art core facilities, provides an outstanding environment in which research academics can be embedded and supported.

Priority areas include:

  • Cell matrix and regenerative medicine – Developing new interdisciplinary research programmes from the mechanisms underpinning cell matrix interactions within tissue, to understanding tissue development, stem cell biology and regeneration, through to clinical application, developing engineered tissues utilising novel biomaterials and delivering novel cell and gene therapies for patient benefit.
  • Biological clocks and timing – This group brings together researchers studying biological clocks using model organisms to understand the underlying fundamental cellular events, with those attempting to use this knowledge for clinical intervention in human diseases, including diabetes and inflammatory arthritis.

Data sciences and precision medicine

The Faculty has great strengths in broad areas of quantitative theory approaches for biomedical research. These include health and bio-informatics data analytics, systems medicine and biostatistics, strengthened by the Health e-Research Centre (HeRC).

With links to our sister Faculty of Science and Engineering, which has widely acknowledged strengths in the underlying areas of computational science, mathematics, text-mining, and software engineering, the University provides a vibrant, exciting environment for researchers in data sciences.

Precision medicine is one of our major research themes that cuts across many of our research activities (linking big data, clinical genomics, quantitative biology, patient stratification and single cell ‘omics’). These links are brought together by the Manchester Precision Medicine Institute, which partners with the MAHSC partner NHS Foundation Trusts, and Industry.

Within the Faculty, priority areas within data science and precision medicine are:

  • Precision medicine – Combines our strengths in immune-mediated inflammatory diseases and the opportunities presented by DevoManc to carry out world-leading research in precision medicine and provide a test-bed for the validation and verification of biomarker-based diagnostics.
  • Integrated computational and mathematical methodologies – Focussing on bringing together theory and experimentation through integration of computational and mathematical methodologies across the University, to develop novel methodologies for data analysis.
  • Learning health systems –Combining theoretical and empirical approaches in learning health systems research across Manchester’s excellence in health-care management, social policy, health economics, health services research, medical sociology, and psychology and health informatics.

Inflammation and immunity

The Faculty hosts the Manchester Immunology Group and the Manchester Collaborative Centre for Inflammation Research (MCCIR). Manchester Immunology Group investigates fundamental and translational immunity, and cellular inflammatory processes, with particular strengths in parasitic infections, mucosal immunity and innate immune mechanisms. MCCIR studies the regulation of immunity across the life course in health and disease.

Research is carried out with the Infection Immunity, Inflammation and Repair research domain across four overlapping areas:

  • Explorative immunology across the life course
  • Regenerative medicine, including matrix biology
  • Chronic inflammatory diseases, focusing primarily on musculoskeletal, dermatological and respiratory conditions
  • Infection, including mycology, bacteriology and parasite immunology

Priority areas include:

  • Immunology – Research spanning basic science, paediatric, infectious disease, respiratory, dermatology, auto-immunity, cancer, rare diseases, and geriatric and vaccine immunology.
  • Wound healing – developing novel interdisciplinary research activity, aimed at new discoveries in the initiation and treatment of complex, chronic wounds.
  • Cancer immunology – combining research in inflammatory disease and cancer biology to study the role of inflammation in the early development of many tumour types.

To find out more about our research activities, select a research domain from the list below:

The award

The Presidential Research Fellowships in Biology, Medicine and Health offer a three-year contract (£31,604-£49,149 dependent on experience) plus up to £10,000 per annum for research support costs and access to key technology platforms. Presidential Research Fellows will be expected to seek external fellowship support. Fellows may have the opportunity to engage in minimal teaching.

This award is available to basic science researchers (inclusive of health service researchers and social scientists) – normally with three to seven years of postdoctoral experience – who are looking to apply for intermediate-level fellowships. A further call will be announced in the autumn aimed at clinicians who already hold a PhD and who have completed (or are soon to complete) clinical specialist training, and who wish to apply for clinical intermediate/senior fellowships.

The award is open to internal candidates and those applying from outside the University.

The University of Manchester is committed to building a culturally diverse institution where all staff and students can flourish and feel valued for their contribution and individuality. Our policies and practices are designed to encourage talented people, whatever their background, to work and study here. All appointments are made on merit.

Applications from disciplines within biology, medicine and health should be submitted here.

Please read the guidance documentation thoroughly to ensure you upload all the requested documents with your application. FAQs are available here.

The closing date for applications was Tuesday, 3 April 2018. A further call for applications will be announced in the Autumn aimed at clinicians who already hold a PhD and who have completed (or soon to complete) clinical specialist training.

 

 

Biology, Medicine and Health